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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PRKAR2A
All Species:
41.82
Human Site:
S264
Identified Species:
61.33
UniProt:
P13861
Number Species:
15
Phosphosite Substitution
Charge Score:
0.13
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P13861
NP_004148.1
404
45518
S264
E
S
V
P
L
L
K
S
L
E
V
S
E
R
M
Chimpanzee
Pan troglodytes
XP_001148361
477
52826
S338
E
S
L
P
F
L
K
S
L
E
F
S
E
R
L
Rhesus Macaque
Macaca mulatta
XP_001089109
461
51060
S322
E
S
L
P
F
L
K
S
L
E
F
S
E
R
L
Dog
Lupus familis
XP_541890
401
45078
S261
E
S
V
P
L
L
K
S
L
E
M
S
E
R
M
Cat
Felis silvestris
Mouse
Mus musculus
P12367
401
45371
S261
E
S
V
P
L
F
K
S
L
E
M
S
E
R
M
Rat
Rattus norvegicus
P12368
401
45522
S261
E
S
V
P
L
F
K
S
L
E
M
S
E
R
M
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001509189
323
36258
D204
I
G
T
K
I
Y
K
D
G
E
Q
I
I
A
Q
Chicken
Gallus gallus
Q5ZM91
382
43332
S259
S
K
V
S
I
L
E
S
L
D
K
W
E
R
L
Frog
Xenopus laevis
NP_001084637
402
45172
S263
E
S
L
P
F
L
K
S
L
E
F
S
E
R
L
Zebra Danio
Brachydanio rerio
NP_001070838
397
44672
S261
E
S
I
P
L
L
K
S
L
E
L
S
E
R
M
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P81900
377
42730
A245
N
S
V
P
M
L
K
A
L
Q
N
Y
E
R
M
Honey Bee
Apis mellifera
XP_392905
383
43849
S251
N
K
V
P
M
L
K
S
L
E
P
Y
E
R
M
Nematode Worm
Caenorhab. elegans
P30625
366
41449
D243
S
K
V
Q
I
L
A
D
L
D
Q
W
E
R
A
Sea Urchin
Strong. purpuratus
Q26619
369
41770
S242
E
K
V
S
I
F
K
S
L
E
P
Y
E
R
M
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
P07278
416
47201
I281
D
R
L
T
F
R
K
I
L
L
G
S
S
F
K
Red Bread Mold
Neurospora crassa
Q01386
385
42138
T264
E
E
V
P
I
L
K
T
L
T
P
Y
E
R
S
Conservation
Percent
Protein Identity:
100
58.4
61.1
91
N.A.
86.8
86.8
N.A.
58.6
35.1
64.8
71.2
N.A.
48.7
49.7
32.9
52.2
Protein Similarity:
100
68.3
70.7
94.5
N.A.
91.3
92
N.A.
69
52.7
80.6
83.6
N.A.
67.8
69
54.9
69
P-Site Identity:
100
73.3
73.3
93.3
N.A.
86.6
86.6
N.A.
13.3
40
73.3
86.6
N.A.
60
66.6
33.3
60
P-Site Similarity:
100
86.6
86.6
100
N.A.
93.3
93.3
N.A.
20
66.6
86.6
100
N.A.
80
73.3
46.6
66.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
37.2
35.4
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
55.2
51.4
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
20
53.3
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
33.3
66.6
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
0
7
7
0
0
0
0
0
7
7
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
7
0
0
0
0
0
0
13
0
13
0
0
0
0
0
% D
% Glu:
63
7
0
0
0
0
7
0
0
69
0
0
88
0
0
% E
% Phe:
0
0
0
0
25
19
0
0
0
0
19
0
0
7
0
% F
% Gly:
0
7
0
0
0
0
0
0
7
0
7
0
0
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
7
0
7
0
32
0
0
7
0
0
0
7
7
0
0
% I
% Lys:
0
25
0
7
0
0
88
0
0
0
7
0
0
0
7
% K
% Leu:
0
0
25
0
32
69
0
0
94
7
7
0
0
0
25
% L
% Met:
0
0
0
0
13
0
0
0
0
0
19
0
0
0
50
% M
% Asn:
13
0
0
0
0
0
0
0
0
0
7
0
0
0
0
% N
% Pro:
0
0
0
69
0
0
0
0
0
0
19
0
0
0
0
% P
% Gln:
0
0
0
7
0
0
0
0
0
7
13
0
0
0
7
% Q
% Arg:
0
7
0
0
0
7
0
0
0
0
0
0
0
88
0
% R
% Ser:
13
57
0
13
0
0
0
69
0
0
0
57
7
0
7
% S
% Thr:
0
0
7
7
0
0
0
7
0
7
0
0
0
0
0
% T
% Val:
0
0
63
0
0
0
0
0
0
0
7
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
13
0
0
0
% W
% Tyr:
0
0
0
0
0
7
0
0
0
0
0
25
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _